FLUORESCENT PROBE FOR HIGH-SENSITIVITY PANCREATIC FLUID DETECTION, AND METHOD FOR DETECTING PANCREATIC FLUID

摘要

[Problem];To provide a fluorescent probe capable of rapidly detecting and imaging with high sensitivity the presence of leakage of pancreatic fluid during or after surgery, and to furthermore provide a detection method and detection kit that use the fluorescent probe.;[Solution];A fluorescent probe for detecting pancreatic fluid containing a compound or salt thereof represented by formula (I) below.;;(In the formula, A represents an amino acid residue or N-substituted amino acid residue, with A forming an amide bond with the adjacent NH in the formula; R1 represents a hydrogen atom or 1 to 4 same or different substituent groups that bond with a benzene ring; R2, R3, R4, R5, R6, and R7 each independently represent a hydrogen atom, a hydroxyl group, an alkyl group, or a halogen atom; R8 and R9 each independently represent a hydrogen atom or an alkyl group; and X represents a C1-C3 alkylene group.)

主权项

1. A fluorescent probe for pancreatic fluid detection, comprising a compound represented by the following to (I) or a salt thereof: wherein A represents an amino acid residue or an N-substituted amino acid residue, where A links to the adjacent NH in the formula by forming an amide bond: R1 represents a hydrogen atom, or one substituent group or two to four substituent groups which are identical to or different from each other binding to the benzene ring; R2, R3, R4, R5, R6, and R7 each independently represents a hydrogen atom, a hydroxy group, an alkyl group, or a halogen atom; R8 and R9 each independently represents a hydrogen atom or an alkyl group; and X represents alkylene group.