ENDO-(14S)-3-METHOXY-17-METHYLMORPHINAN PICRATE AND PREPARATION METHOD AND USE THEREOF

摘要

During the long-term commercial process for producing dextromethorphan hydrobromide, large amounts of endo-(14S)-3-methoxy-17-methylmorphinan are required for use in the aspects of quality control, however, endo-(14S)-3-methoxy-17-methylmorphinan is unstable, inconvenience for storage, and also goes against the execution of the testing procedure, and hence it is imperative to solve the practical problem generated in this production process in the art. In view of this, disclosed in the present invention is endo-(14S)-3-methoxy-17-methylmorphinan picrate in the form of a solid and a preparation method and use thereof, i.e. being used for detecting endo-(14S)-3-methoxy-17-methylmorphinan in the process for synthesizing dextromethorphan.