| 发明名称 |
COMPOSITIONS AND METHODS FOR MODULATING IMMUNE RESPONSES |
| 摘要 |
The present invention provides a newly identified B7 receptor, zB7R1 that functions as lymphocyte inhibitory receptor, which is a PD-1-like molecule and is expressed on T cells. The present invention also provides the discovery of zB7R1's ability to bind to CD155. Methods and compositions for modulating zB7R1-mediated negative signaling and interfering with the interaction of its counter-receptor for therapeutic, diagnostic and research purposes are also provided. |
| 申请公布号 |
US2015152160(A1) |
申请公布日期 |
2015.06.04 |
| 申请号 |
US201414300724 |
申请日期 |
2014.06.10 |
| 申请人 |
ZymoGenetics, Inc. |
发明人 |
GAO Zeren;Levin Steven D.;Bilsborough Janine M.;West James W.;Brandt Cameron S.;Chadwick Eric M. |
| 分类号 |
C07K14/705;C07K14/47;C12Q1/66;C07K16/28 |
主分类号 |
C07K14/705 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating an immune related disorder in a mammal by administering to said mammal a therapeutically effective amount of a zB7R1 fusion protein. |
| 地址 |
Princeton NJ US |
