| 发明名称 |
SERUM ALBUMIN BINDING MOLECULES |
| 摘要 |
The present invention relates to an antibody-like protein based on the tenth fibronectin type III domain (10Fn3) that binds to serum albumin. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications. |
| 申请公布号 |
US2015152147(A1) |
申请公布日期 |
2015.06.04 |
| 申请号 |
US201414552823 |
申请日期 |
2014.11.25 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
GOSSELIN Michael L.;FABRIZIO David;SWAIN Joanna F.;MITCHELL Tracy;CAMPHAUSEN Ray;CLOAD Sharon T.;FURFINE Eric;MORIN Paul E.;MUKHERJEE Ranjan;TAYLOR Simeon I. |
| 分类号 |
C07K14/435;C07K14/575;C07K14/50 |
主分类号 |
C07K14/435 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A polypeptide comprising a fibronectin type III tenth (10Fn3) domain, wherein the 10Fn3 domain binds to domain 1 or 2 of human serum albumin with a KD of 1 uM or less, and wherein the serum half-life of the polypeptide in the presence of albumin is at least 5-fold greater than the serum half-life of the polypeptide in the absence of serum albumin. |
| 地址 |
PRINCETON NJ US |
