发明名称 |
METHODS TO REDUCE ADVERSE EVENTS CAUSED BY PHARMACEUTICAL PREPARATIONS COMPRISING PLASMA DERIVED PROTEINS |
摘要 |
The instant invention provides a method to reduce adverse events caused by a pharmaceutical preparation derived from a plasma fraction said plasma fraction comprising antithrombin III wherein the method comprises contacting the plasma fraction with heparin or a heparin-like substance thereby reducing the activity of at least one activated serine protease per ml of the plasma fraction. |
申请公布号 |
US2015150911(A2) |
申请公布日期 |
2015.06.04 |
申请号 |
US201214116491 |
申请日期 |
2012.05.14 |
申请人 |
Schulte Stefan;Kalina Uwe;Moses Michael;Feussner Annette |
发明人 |
Schulte Stefan;Kalina Uwe;Moses Michael;Feussner Annette |
分类号 |
A61K35/16 |
主分类号 |
A61K35/16 |
代理机构 |
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代理人 |
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主权项 |
1. A method of removing activated serine proteases from a plasma fraction comprising antithrombin III, wherein the method comprises contacting the plasma fraction with heparin or a heparin-like substance covalently bound to a matrix, wherein the activity of at least one activated serine protease per ml of the plasma fraction is reduced. |
地址 |
Marburg DE |