SAMPLE PROCESSING SYSTEM FOR PROCESSING BIOLOGICAL SAMPLES

摘要

The invention relates to a sample processing system and method for processing biological samples, particularly bodily fluids like blood, saliva, secretions and the like or tissue samples, particularly for preparation of samples for a DNA analysis by means of PCR, comprising a sample processing device (12) having: an receiving plate (14), wherein the receiving plate (14) is arranged substantially horizontally in a plane defined by a first and second direction (x, y); a first and second working arm (20, 22), wherein the first and second working arm (20, 22) can move relative to the receiving plate (14), preferably along a first edge (18) of the receiving plate (14) in the first direction (X), and wherein the first and second working arm (20, 22) extend substantially parallel to each other in the second direction (Y) over the receiving plate (14), wherein at least one pipetting device (40, 42) is mounted on the first working arm (20) which is movable in the second direction (Y) and in a third direction (Z) orthogonal in relation to the first and second direction (X, Y) and wherein at least one gripping device (50) is mounted on the second working arm (22) which is movable in the second direction (Y) and in a third direction (Z) orthogonal in relation to the first and second direction (X, Y), wherein grippers (54) provided on the gripping device (50) can be rotated around a gripper axis of rotation (GA) parallel to the third direction (Z); and a control device for controlling the pipetting device (40, 42) and the gripping device (50). The system further comprises a plurality of sample containers (68) filled with samples, particularly liquid samples, or fillable with samples or reagents, a plurality of pipetting tips (48) which can be used by means of the pipetting device (48) for aspiring and dispensing sample fluid or additional reagents required for the sample processing, such as a lysis buffer, wherein the sample containers (68) and the pipetting tips (48) are arranged on the receiving plate (14) by means of corresponding sample container carriers (64, 66) and/or pipetting tip carriers (44). According to the invention the control device is arranged such that a sample fluid, particularly of liquid biological material or a mixture of at least one reagent with biological material to be dissolved or dissolved, in a sample container (68) is, by means of the gripper device (50), mixed by rotation of a sample holder (68), held by means of the gripper (54), around the gripper axis of rotation (GA), preferably at approximately 500 to 2000 revolutions per minute.

主权项

1. Sample processing system for processing of biological samples, in particular bodily fluids as blood, saliva, secretions and the like or tissue samples, in particular for preparation of samples for a DNA analysis by PCR, comprising
a sample processing device (12)
with a receiving plate (14), wherein the receiving plate (14) is arranged essentially horizontally in a plane defined by a first and a second direction (X, Y);with a first and a second working arm (20, 22), wherein the first and second working arm (20, 22) are movable along the first direction (X) relative to the receiving plate (14), preferably along a first edge (18) of the receiving plate (14), and wherein the first and the second working arm (20, 22) extend essentially in parallel with respect to each other along the second direction (Y) across the receiving plate (14), wherein on the first working arm (20) at least one pipetting device (40, 42) movable along the second direction (Y) and along a third direction (Z) orthogonal to the first and the second directions (X, Y) is attached and wherein at the second working arm (22) at least one gripping device (50) movable along the second direction (Y) and along a third direction (Z) orthogonal to the first and the second directions (X, Y) is attached, wherein grippers (54) provided on the gripping device (50) are rotatable around a gripper axis of rotation (GA) parallel to the third direction (Z); andwith a control device for controlling the pipetting device (40, 42) and the gripping device (50); a plurality of sample containers (68) filled with samples, in particular liquid samples, or fillable with samples or reagents, a plurality of pipetting tips (48) usable by means of the pipetting device (40, 42) for aspirating and dispensing of sample liquid or further reagents necessary for the sample processing, such as a lysis-buffer, wherein the sample containers (68) and the pipetting tips (48) are arranged by means of corresponding sample container carriers (64, 66) and pipetting tip carriers (44) on the receiving plate (14), respectively, characterized in that the control device is configured such that a sample liquid contained in a sample container (68), in particular of liquid biological material or of a mixture of at least one reagent with biological material to be dissolved or dissolved, is mixed by means of the gripping device (50) by rotating a sample container (68) gripped by the grippers (54) around the gripper axis of rotation (GA), preferably with about 500 to 2000 revolutions per minute.