发明名称 |
FUSION PROTEINS, USES THEREOF AND PROCESSES FOR PRODUCING SAME |
摘要 |
This invention provides fusion proteins comprising consecutive amino acids which beginning at the amino terminus of the protein correspond to consecutive amino acids present in (i) a cytomegalovirus human MHC-restricted peptide, (ii) a first peptide linker, (iii) a human β-2 microglobulin, (iv) a second peptide linker, (v) a HLA-A2 chain of a human MHC class I molecule, (vi) a third peptide linker, (vii) a variable region from a heavy chain of a scFv fragment of an antibody, and (viii) a variable region from a light chain of such scFv fragment, wherein the consecutive amino acids which correspond to (vii) and (viii) are bound together directly by a peptide bond or by consecutive amino acids which correspond to a fourth peptide linker, wherein the antibody from which the scFv fragment is derived specifically binds to mesothelin. |
申请公布号 |
US2015152161(A1) |
申请公布日期 |
2015.06.04 |
申请号 |
US201414526667 |
申请日期 |
2014.10.29 |
申请人 |
Technion Research & Development foundation Limited |
发明人 |
REITER Yoram;Noy Roy;Oved Kfir |
分类号 |
C07K14/74;C07K16/30 |
主分类号 |
C07K14/74 |
代理机构 |
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代理人 |
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主权项 |
1. A fusion protein comprising consecutive amino acids which, beginning at the amino terminus of the protein, correspond to consecutive amino acids present in (i) a cytomegalovirus human MHC-restricted peptide, (ii) a first peptide linker, (iii) a human β-2 microglobulin, (iv) a second peptide linker, (v) a HLA-A2 chain of a human MHC class I molecule, (vi) a third peptide linker, (vii) a variable region from a heavy chain of a scFv fragment of an antibody, and (viii) a variable region from a light chain of such scFv fragment, wherein the consecutive amino acids which correspond to (vii) and (viii) are bound together directly by a peptide bond or by consecutive amino acids which correspond to a fourth peptide linker and the scFv fragment is derived from an antibody which specifically binds to mesothelin. |
地址 |
Haifa IL |