MICROREACTOR AND METHOD FOR PREPARING A RADIOLABELED COMPLEX OR A BIOMOLECULE CONJUGATE

摘要

A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for incubating a mixed fluid. The reservoir is in fluid communication with the microchannel and is disposed downstream of the mixing portion. A method of preparing a radiolabeled complex includes flowing a radiometal solution comprising a metallic radionuclide through a downstream mixing portion of a microchannel, where the downstream mixing portion includes one or more passive mixing elements, and flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion. The ligand solution and the radiometal solution are passively mixed while in the downstream mixing portion to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator. The chelation reaction is completed to form a radiolabeled complex.

主权项

1. A microreactor for preparing a radiolabeled complex or a biomolecule conjugate, the microreactor comprising:
a microchannel for fluid flow, the microchannel including an upstream mixing portion and a downstream mixing portion each comprising one or more passive mixing elements; a first inlet upstream of the upstream mixing portion for introduction of a first reagent; a second inlet upstream of the upstream mixing portion for introduction of a second reagent; a third inlet between the upstream mixing portion and the downstream mixing portion for introduction of a third reagent; and at least one reservoir for incubating a mixed fluid, the at least one reservoir being in fluid communication with the microchannel and disposed downstream of the downstream mixing portion.