| 摘要 |
A method of detecting a species of nucleic acid in a sample, comprising contacting the sample with a set of probes, wherein each probe specifically recognises a distinct target sequence, providing conditions under which the target sequences are at least partially single stranded, providing conditions for annealing and ligation, under which conditions the probes hybridise to their target sequences and generate ligation products, each ligation product comprising a ligation junction, and detecting a cumulative signal which is a combination of individual signals from all ligation products, wherein detection of the signal indicates the presence of the species of nucleic acid in the sample. |
