PROCESS FOR PRODUCING ESTER COMPOUND

摘要

Compound (1) or a salt that is useful as an intermediate for the production of a medicine, an agrochemical or the like can be produced by a process comprising steps A to G as mentioned below:
[Step A] A step of reacting an aldehyde compound (2) with nitromethane to produce a nitroaldehyde compound (3);
[Step B] A step of reacting the nitroaldehyde compound (3) with an alcohol to produce a nitroacetal compound (4);
[Step C] A step of reducing the nitroacetal compound (4) to produce an aminoacetal compound (5);
[Step D] A step of protecting an amino group in the aminoacetal compound (5) to produce a protected aminoacetal compound (6);
[Step E] A step of treating the protected aminoacetal compound (6) with an acid and aubsequently with a base and then reacting the resultant product with a cyanating agent to produce a nitrile compound (7);
[Step F] A step of hydrolyzing the nitrile compound (7) to produce a protected amino acid compound (8); and
[Step G] A steep of substituting a group R 5 in the protected amino acid compound (8) by a hydrogen atom and protecting a carboxyl group therein.