发明名称 |
PHENYLETHANOIC ACID, PHENYLPROPANOIC ACID AND PHENYLPROPENOIC ACID CONJUGATES AND PRODRUGS OF HYDROCODONE, METHODS OF MAKING AND USE THEREOF |
摘要 |
The presently described technology provides phenylethanoic acid, phenylpropanoic acid, phenylpropenoic acid, a salt thereof, a derivative thereof or a combination thereof chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs or compositions of hydrocodone which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology. |
申请公布号 |
EP2448408(A4) |
申请公布日期 |
2015.06.03 |
申请号 |
EP20100794765 |
申请日期 |
2010.07.01 |
申请人 |
KEMPHARM, INC. |
发明人 |
MICKLE, TRAVIS;GUENTHER, SVEN;MICKLE, CHRISTAL;CHI, GUOCHEN;KANSKI, JAROSLAW;MARTIN, ANDREA, K.;BERA, BINDU |
分类号 |
A01N43/42;A61K31/44;A61K31/485;A61K47/48 |
主分类号 |
A01N43/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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