发明名称 |
Reversible PEGylation of nanocarriers |
摘要 |
The present invention relates to the preparation and use of reversibly PEGylated nanocarriers. The reversibly PEGgylated nanocarrier system comprises an inner core comprising or consisting of a nanoparticle and/or at least one pharmaceutical compound; optionally at least one lipid bilayer on the surface of the inner core; a first ligand bound to the surface of said inner core, or if present, to the surface of the at least one lipid bilayer; a second ligand bound to the first ligand, the second ligand being covalently bound to poly(ethylene glycol) or a derivative thereof. The reversibly PEGgylated nanocarrier system is characterized in that binding of the second ligand to the first ligand is non-covalent and reversible. Pharmaceutical compositions and use of such compounds and compositions in the field of e.g. cancer therapy, gene therapy, inflammatory diseases and pain therapy are also disclosed. |
申请公布号 |
EP2878312(A1) |
申请公布日期 |
2015.06.03 |
申请号 |
EP20130195337 |
申请日期 |
2013.12.02 |
申请人 |
ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG |
发明人 |
PROF. DR. WEBER, WILFRIED;REBMANN, BALDER;ZURBRIGGEN, MATIAS |
分类号 |
A61K47/48;A61K9/127;A61P35/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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