Method for chemical synthesis of antrocin and use thereof for suppressing non-small cell lung cancer

摘要

The present invention provides a method for preparing antrocin of pharmaceutically acceptable salts thereof via a series of gold-catalyzed cyclization to construct the (6-6-5) tricyclic core frame. The present invention also provides a use of a composition in preparing drugs for suppressing growth of non-small cell lung cancer cells, wherein the composition comprises an effective amount of antrocin or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier.

主权项

1. A method for preparing antrocin, comprising the steps of:
(a) reacting Compound A with sulfide and haloalkane in the presence of a base to produce an intermediate; and (b) reacting the intermediate with a free radical initiator and a free radical source to form antrocin.