Neuritogenic peptides

摘要

The present invention relates to peptide compounds that are capable of stimulating neuronal differentiation, neurite outgrowth and survival of neural cells, and enhancing synaptic plasticity, learning and memory, methods of treating diseases and conditions of nervous system by administration of compositions comprising said compounds. The compounds and compositions of the invention include peptide sequences that are derived from the sequence of human erythropoietin or proteins that are homologous of human erythropoietin.

主权项

1. A method for treating a condition of the central nervous system selected from Alzheimer's disease, epilepsy, and traumatic brain injury, said method comprising administering to a subject in need thereof an effective amount of (i) a peptide consisting of 10 to 20 consecutive amino acids of SEQ ID NO:3; or (ii) a peptide consisting of 10 to 20 amino acids and having more than 80% homology to 10 to 20 consecutive amino acids of SEQ ID NO:3;
wherein said peptide is capable of stimulating neurite outgrowth, and/or promoting survival of neural cells, and/or stimulating neural cell proliferation.