发明名称 |
Compositions and methods for treating cancer and other diseases |
摘要 |
Aptamers and improved aptamers are provided with enhanced efficacy for binding to target molecules in vivo or for treating cancer or other diseases. Such improvements in aptamers are provided that enhance in vivo efficacy such as binding to the target molecule or enhancing anti-cancer activity. Such improvements also include stability to serum nucleases, reduced binding to a soluble form of the target molecule, increased avidity, affinity or specificity to the target molecule on a cell surface, increased lifetime in circulation, or any combination of the foregoing. Improvements are provided by truncation, multimerization, including at least one non-natural nucleic acid, adding a 3′ or 5′ polyethylene glycol, or any combination thereof. Aptamers for treatment of autoimmune diseases are also provided. |
申请公布号 |
US9045756(B2) |
申请公布日期 |
2015.06.02 |
申请号 |
US201013510221 |
申请日期 |
2010.11.16 |
申请人 |
MEMORIAL SLOAN KETTERING CANCER CENTER |
发明人 |
Scheinberg David A.;Mallikaratchy Prabodhika |
分类号 |
C07H21/02;C07H21/04;C12N15/115;A61K31/711;C12Q1/68 |
主分类号 |
C07H21/02 |
代理机构 |
Pearl Cohen Zedek Latzer Baratz LLP |
代理人 |
Cohen Mark S.;Pearl Cohen Zedek Latzer Baratz LLP |
主权项 |
1. A multivalent aptamer having the sequence represented by SEQ ID NO:16, SEQ ID NO:15, SEQ ID NO:19or SEQ ID NO:20. |
地址 |
New York NY US |