Compounds

摘要

The present invention is directed to sulphated compounds comprising at least one glycosidic amine group, and polysaccharide, oligosaccharide, peptide and protein derivatives comprising such compounds, and mixtures thereof. The present invention is also directed to methods of synthesizing such compounds. Such compounds may bind to a range of proteins, find application in methods of modifying, or testing for a modification in the level of a cytokine in vivo, ex vivo or in vitro, and find application in the treatment and/or prevention of inflammation, an inflammatory disorder, a proliferative disorder, an immune disorder, an angiogenesis-dependent disorder, a sensitivity disorder, an adverse endocrine reaction, a degenerative disorder, wound healing, depression, and other diseases and disorders.

主权项

1. A compound comprising:
(i) a sequence of at least two monosaccharide subunits directly linked by a glycosidic —NR— group or a glycosidic —NR2+— group, wherein the glycosidic —NR— group or the glycosidic —NR2+— group is linked to both of the monosaccharide subunits by a glycosidic bond, and wherein each R is independently hydrogen, a —SO2—OR′ or —SO2—N(R′)2 group, a further monosaccharide subunit, or a hydrocarbyl group, or two R groups and the nitrogen atom to which they are attached, together form a further monosaccharide subunit or a cyclic hydrocarbyl group; and (ii) at least one sulphate group, wherein a sulphate group is a —O—SO2—OR′, —NR′—SO2—OR′, —O—SO2—N(R′)2 or —NR′—SO2—N(R′)2 group;wherein each R′ is independently hydrogen, a metal, a further monosaccharide subunit, or a hydrocarbyl group;wherein each monosaccharide subunit independently is optionally substituted and/or optionally modified; andwherein each hydrocarbyl group independently is a substituted or unsubstituted, straight-chain, branched or cyclic alkyl, alkenyl, alkynyl, acyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, alkylaryl, alkenylaryl or alkynylaryl group which optionally includes one or more heteroatoms in its carbon skeleton;or a salt thereof.