Method and probe set for detecting cancer

摘要

Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if aneusomic cells are present in a selected subset of cells obtained from the biological sample are described. A set of chromosomal probes and kits for detecting cancer that include sets of chromosomal probes, are also described.

主权项

1. A method of detecting bladder cancer comprising:
(a) obtaining a kit comprising a set of detectably labeled chromosomal probes consisting of centromeric probes to chromosomes 3, 7, and 17 or centromeric chromosomal probes to chromosomes 3, 7, 17 and a locus-specific probe to 9p21, wherein the probes are fluorescently labeled such that each probe can be distinctly visualized in a hybridization pattern; (b) hybridizing said set of chromosomal probes of said kit to cells obtained from a urine sample from a subject; and (c) detecting bladder cancer by identifying aneusomic cells from the hybridization pattern of said set of chromosomal probes in cells from said urine sample.