| 发明名称 | Oncolytic rhabdovirus | ||
| 摘要 | Embodiments of the invention include compositions and methods related to Maraba virus and their use as anti-cancer therapeutics. Such rhabdoviruses possess tumor cell killing properties in vitro and in vivo. | ||
| 申请公布号 | US9045729(B2) | 申请公布日期 | 2015.06.02 |
| 申请号 | US201013514837 | 申请日期 | 2010.12.10 |
| 申请人 | Ottawa Hospital Research Institute;Children's Hospital of Eastern Ontario Research Institute Inc. | 发明人 | Bell John C.;Stojdl David F. |
| 分类号 | A61K39/245;C12N7/00;A61K45/06 | 主分类号 | A61K39/245 |
| 代理机构 | Borden Ladner Gervais LLP | 代理人 | Nauman David;Borden Ladner Gervais LLP |
| 主权项 | 1. An attenuated rhabdovirus comprising: an M protein having an amino acid sequence that is at least 85% identical to the amino acid sequence of SEQ ID NO:4 and a tryptophan at the position corresponding to position 123 of SEQ ID NO:4, or both a G protein having an amino acid sequence that is at least 80% identical to the amino acid sequence of SEQ ID NO: 5 and an arginine at the position corresponding to position 242 of SEQ ID NO:5 and an M protein having an amino acid sequence that is at least 80% identical to the amino acid sequence of SEQ ID NO:4 and a tryptophan at the position corresponding to position 123 of SEQ ID NO:4. | ||
| 地址 | Ottawa CA | ||