Controlling allergy and asthma by activating human DCs via Dectin-1 or toll-like receptor 2 (TLR2)

摘要

The present invention includes compositions and methods for enhancing Th1/Th17 cell responses and decreasing Th2 cell responses. In various embodiments the present invention describes activation of human dendritic cells and enhancement of antigen-specific T cell responses in a Dectin-1-expressing human dendritic cells comprising an anti-Dectin-1-specific antibody or fragment thereof fused with one or more antigens. TLR2 ligands may also be included to enhance the activation and for enhancement of T-cell responses. Further, the invention also includes methods based on the compositions described herein for the treatment of allergy, and asthma.

主权项

1. A method for treating allergy, asthma, or both in a subject having allergy, asthma, or both, the method comprising administering a Dectin-1 agonist and P. gingivalis LPS to the subject wherein the Dectin-1 agonist is an anti-Dectin-1-specific antibody or fragment thereof.