发明名称 |
2-aryl-4-quinazolinones and their pharmaceutical compositions |
摘要 |
Provided is a compound of the formula I or a pharmaceutically acceptable salt, solvate or stereoisomer thereof:;wherein Ar represents;R5, R7, R8, R2′, R3′, R4′, R5′, R6′, R7′, R8′ independently represent H, OH, F, Cl, Br methoxyl group, NH2 group or NMe2 group; X represents NH, O or S; R6 is selected from the group consisting of: piperidinyl group, morpholino group, methoxyl group, and dimethylamine group. The present invention also provides a composition comprising the compound of formula I. The compound and the composition in accordance with the present invention are effective on treating or alleviating a disease or disorder, such as malignant glioma. |
申请公布号 |
US9045437(B2) |
申请公布日期 |
2015.06.02 |
申请号 |
US201313953882 |
申请日期 |
2013.07.30 |
申请人 |
China Medical University |
发明人 |
Hour Mann-Jen;Gean Po-Wu;Kuo Sheng-Chu;Lee Hong-Zin;Yang Jai-Sing;Chou Li-Chen;Chen Tai-Lin;Wu Yang-Chang |
分类号 |
C07D239/91;C07D403/04;C07D409/04 |
主分类号 |
C07D239/91 |
代理机构 |
Fishman & Associates, LLC. |
代理人 |
Fishman & Associates, LLC. |
主权项 |
1. A compound of the formula I or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof: wherein R5, R7 and R8 independently represent H, OH, F, Cl, Br methoxyl group, NH2 group or NMe2 group; Ar represents R2′, R3′, R4′, R5′, R6′, R7′, R8′ independently represent H, OH, F, Cl, Br, methoxyl group, NH2 group or NMe2 group; wherein R6 is selected from the group consisting of: piperidinyl group, pyrrolidinyl group, morpholino group, methoxyl group, and N,N-dimethylamino group. |
地址 |
Taichung TW |