Method for delivering drugs to the brain

摘要

The present invention is concerned with delivering a pharmaceutical composition to the brain of a mammalian subject for treating brain diseases or disorders. The process includes the steps of: (i) providing a dispersion of the pharmaceutical composition as particles having an average particle size of from about 150 nm to about 100 microns, and (ii) administering the dispersion to the mammalian subject for delivery to the brain of a portion of the pharmaceutical composition by cells capable of reaching the brain. The dispersion of the pharmaceutical composition as particles, for example, can be phagocytized or adsorbed by the cells prior or subsequent to administration into the mammalian subject. The dispersion of the pharmaceutical composition can be administered to the central nervous system or the vascular system. After administration, the loaded cells transport the pharmaceutical composition as particles into the brain.

主权项

1. A method for delivering a pharmaceutical composition to a brain of a mammalian subject, the method comprising the steps of:
(i) forming a dispersion of a pharmaceutical composition as particles having an average particle size of from about 150 nm to about 150 microns, wherein the pharmaceutical composition comprises a therapeutic agent; (ii) isolating cells from the mammalian subject, wherein the cells are capable of phagocytosis and are selected from the group consisting of macrophages, monocytes, granulocytes, neutrophils, basophils, eosinophils, and combinations thereof; (iii) contacting the cells with the dispersion of the pharmaceutical composition; (iv) allowing for cell uptake of a portion of the particles to form loaded cells; and (v) administering to the mammalian subject the loaded cells to deliver an effective amount of the pharmaceutical composition to the brain.