Sensors for detecting substances in bodily fluids

摘要

A system is disclosed that extracts bodily fluid to a reaction chamber for monitoring a substance or property of the patient fluid. In one embodiment, a pump is used to advance the sample of bodily fluid through a filter to produce a filtrate. Another pump advances filtrate into the reaction chamber, while another pump advances reactant into the reaction chamber. A sensor in communication with the reaction chamber determines a concentration of nitric oxide or one of its metabolic products. Methods are also disclosed.

主权项

1. A method of treating a patient with nitrite, the method comprising:
administering nitrite or nitric oxide to the patient; monitoring a level of nitrite within blood of the patient, the monitoring comprising:
contacting a sensor with the blood of the patient;excluding particles with a molecular weight greater than 60 kD from a vicinity around the sensor using a size-exclusion filter;converting nitrite ions included in the vicinity around the sensor to nitric oxide; andmeasuring a concentration of nitric oxide using the sensor.