发明名称 |
Protease stabilized, acylated insulin analogues |
摘要 |
Novel acylated insulin analogues exhibiting resistance towards proteases can, effectively, be administered pulmonary or orally. The insulin analogues contain B25H and A14E or A14H. |
申请公布号 |
US9045560(B2) |
申请公布日期 |
2015.06.02 |
申请号 |
US201313973183 |
申请日期 |
2013.08.22 |
申请人 |
NOVO NORDISK A/S |
发明人 |
Madsen Peter;Kjeldsen Thomas Boerglum;Hoeg-Jensen Thomas;Jakobsen Palle;Tagmose Tina Moeller;Glendorf Tine;Kodra Jaanos Tibor;Garibay Patrick William;Petersen Jacob Sten |
分类号 |
A61K38/28;C07K14/62;A61K38/00 |
主分类号 |
A61K38/28 |
代理机构 |
|
代理人 |
Hu Jianjie |
主权项 |
1. An acylated protease stabilized insulin, wherein the acyl moiety is attached to a lysine residue at position B29 of A14E, B16H, B25H, B29K, desB30 human insulin and the acyl moiety is selected from the group consisting of: |
地址 |
Bagsvaerd DK |