| 发明名称 |
Synthetic ligands for the differentiation of closely related toxins and pathogens |
| 摘要 |
Synthetic ligand compounds and methods of differentiating between Shiga toxin 1 and Shiga toxin 2 are disclosed herein. Another embodiment includes a kit for differentiating between Shiga toxin 1 and Shiga toxin 2. Assay systems and methods for providing an assay are also provided for herein. |
| 申请公布号 |
US9045516(B2) |
申请公布日期 |
2015.06.02 |
| 申请号 |
US200812104390 |
申请日期 |
2008.04.16 |
| 申请人 |
|
发明人 |
Iyer Suri Saranathan;Hatch Duane Michael;Kale Ramesh Ratan;Weiss Alison Ann;Gamage Shantini Dodampe;McGannon Colleen M. |
| 分类号 |
G01N33/00;C07H17/02;C07D495/04;G01N33/569;G01N33/68 |
主分类号 |
G01N33/00 |
| 代理机构 |
Taft Stettinius + Hollister LLP |
代理人 |
Taft Stettinius + Hollister LLP ;Leitzel Adelaide K |
| 主权项 |
1. A method for diagnosing bacterial infections mediated by toxins in a patient comprising obtaining a biological sample from the patient and assaying for the presence of a toxin in a binding assay which uses a compound for detecting said toxins, said compound comprising the general formula (I): wherein: n equals 1, 2, 3, 4, 5 or 6, and A comprises a glycoconjugate wherein said glycoconjugate is selected from the group consisting of: wherein R comprises H; to bind to said toxin; and wherein said toxin is selected from the group consisting of Shiga toxin 1 and Shiga toxin 2. |
| 地址 |
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