Use of aminoindane compounds in treating overactive bladder and interstitial cystitis

摘要

The present application provides methods of using the aminoindane compounds of formula (I) or (II) in treating an overactive bladder or interstitial cystitis by administering one or more of the compounds to a patient.;

主权项

1. A method of treating an overactive bladder, said method comprising administering to a patient in need thereof a therapeutically effective amount of a compound of formula (I) or (II):wherein:
A is phenyl or heteroaryl; R1 and R4 are, independently, C1 to C6 alkyl or CH2CH2OH; or R1 and R4 are joined to form a 4- or 6-membered carbocyclic or heterocyclic ring; R2 is independently selected from the group consisting of hydrogen, halogen, NO2, OH, and C1 to C6 alkoxy; R3 is independently selected from the group consisting of hydrogen, halogen, CN, NO2, NH2, optionally substituted C1 to C6 alkyl, C2 to C6 alkenyl, C2 to C6 alkynyl, OH, CF3, OCF3, SCF3, optionally substituted C1 to C6 alkoxy, C2 to C6 alkynyloxy, heterocyclyloxy, heteroaryloxy, optionally substituted C1 to C6 alkylthio, heteroarylthio, C(O)O(C1 to C6 alkyl), C(O)(C1 to C6 alkyl), C(O)(aryl), C(O)(heterocycle), C(O)NH2, C(O)NH(C1 to C6 alkyl), C(O)NH(aryl), C(O)NH(heterocycle), C(O)NH(heteroaryl), C(O)N(C1 to C6 alkyl)(C1 to C6 alkyl), C(O)N(aryl)(C1 to C6 alkyl), C(S)NH2, optionally substituted aryl, heteroaryl, heterocycle, NHC(O)(C1 to C6 alkyl), NHC(O)(aryl), NHC(O)(heteroaryl), NHC(O)O(C1 to C6 alkyl), N(C1 to C6 alkyl)C(O)(C1 to C6 alkyl), N(C1 to C6 alkyl)C(O)O(C1 to C6 alkyl), NHC(O)NH2, NHC(O)NH(C1 to C6 alkyl), NHC(O)NH(heteroaryl), NHSO2(C1 to C6 alkyl), SO2(C1 to C6 alkyl), SO2NH2, SO2NH(C1 to C6 alkyl), SO2NH(C2 to C6 alkynyl), SO2N(C1 to C6 alkyl)(C1 to C6 alkyl), SO2NH(heteroaryl), NH(C1 to C6 alkyl), N(C1 to C6 alkyl)(C1 to C6 alkyl), N(C1 to C6 alkyl)(C2 to C6 alkenyl), and N(C1 to C6 alkyl)(heterocycle); or q is 2 and two R3 groups are joined to form an optionally substituted 6-membered aryl, optionally substituted 5- or 6-membered carbocyclic ring, or optionally substituted 5- or 6-membered heterocycle or heteroaryl containing 1 to 3 oxygen, nitrogen, or sulfur atoms and 4 or 5 carbon atoms; m is 1 to 5; n is 1 to 3; p is 0 to 2; q is 0 to 4; and X− is a halogen ion, trifluoroacetate, sulfate, phosphate, acetate, fumarate, maleate, citrate, pyruvate, succinate, oxalate, bisulfate, malonate, xinafoate, ascorbate, oleate, nicotinate, saccharinate, adipate, formate, glycolate, L-lactate, D-lactate, aspartate, malate, L-tartrate, D-tartrate, stearate, 2-furoate, 3-furoate, napadisylate, edisylate, isethionate, D-mandelate, L-mandelate, propionate, tartarate, phthalate, hydrochlorate, hydrobromate, nitrate, methanesulfonate, ethanesulfonate, napthalenesulfonate, benzenesulfonate, toluenesulfonate, mesitylenesulfonate, camphorsulfonate or trifluoromethanesulfonate.