Virus-like particles, methods of preparation, and immunogenic compositions

摘要

Briefly described, virus-like particles, methods of preparing virus-like particles, immunogenic compositions that include virus-like particles, and methods of eliciting an immune response using immunogenic compositions that include virus-like particles are described herein. A virus-like particle (VLP) can include a viral core protein that can self assemble into the VLP core and at least one viral surface envelope glycoprotein expressed on the surface of the VLP. The VLP can also optionally include at least one adjuvant molecule expressed on the surface of the VLP.

主权项

1. A virus-like particle (VLP), comprising:
a viral core protein that can self assemble into a VLP core, wherein the viral core protein is influenza M1 core protein; at least one viral surface envelope protein expressed on the surface of the VLP; and at least one adjuvant molecule expressed on the surface of the VLP, wherein at least one adjuvant is flagellin, wherein the VLP is nonreplicative and noninfectious, and wherein the VLP does not contain intact viral nucleic acids.