发明名称 |
3,4-disubstituterede 1 H-pyrazolforbindelser og anvendelse heraf som cyclin-afhængige kinaser (CDK) og glycogensyntase kinase-3- (GSK-3) modulatorer |
摘要 |
<p>The invention provides compounds of the formula (0) or salts or tautomers or N-oxides or solvates thereof for use in the prophylaxis or treatment of disease states and conditions such as cancers mediated by cyclin-dependent kinase and glycogen synthase kinase-3. In formula (0): X is a group R1-A-NR4-or a 5-or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C=O, NRg(C=O) or O(C=O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e.g. fluorine), hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy (e.g. methoxy); or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy); R3 is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy).</p> |
申请公布号 |
DK2256106(T3) |
申请公布日期 |
2015.06.01 |
申请号 |
DK20100175329T |
申请日期 |
2004.07.22 |
申请人 |
ASTEX THERAPEUTICS LIMITED |
发明人 |
BERDINI, VALERIO;CARR, MARIA GRAZIA;WOOLFORD, ALISON JO-ANN;WOODHEAD, ANDREW JAMES;WYATT, PAUL GRAHAM;O'BRIEN, MICHAEL ALISTAIR;EARLY, THERESA RACHEL;GILL, ADRIAN LIAM;TREWARTHA, GARY |
分类号 |
C07D231/38;A61K31/4155;A61P25/28;A61P31/10;A61P31/12;A61P35/00;A61P37/00;C07D231/14;C07D231/40;C07D231/42;C07D401/12;C07D401/14;C07D403/04;C07D403/12;C07D405/12;C07D405/14;C07D409/12;C07D409/14;C07D413/12;C07D413/14;C07D453/02;C07D471/04 |
主分类号 |
C07D231/38 |
代理机构 |
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地址 |
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