Phosphonated rifamycins and derivatives thereof, pharmaceutical compositions comprising the same and uses thereof in the preparation of medicaments for the prevention and treatment of bone and joint infections

摘要

The present invention relates to phosphonated Rifamycins, and methods of making and using such compounds. These compounds are useful as antibiotics for prophylaxis and/or the treatment of bone and joint infections, especially for the prophylaxis and/or treatment of osteomyelitis.