| 摘要 |
<p>Disclosed is an isolated human Tr1 cell population capable of producing IL-13 when activated, wherein said Tr1 cell population secretes an amount of IL-13 of more than 10ng/ml. Also disclosed is an in vitro method of identifying said human Tr1 cell population, comprising: - detecting the cell surface expression of CD4, and at least one of CD127 and CD62L markers on a cell population, - detecting the production of IL-13, or IL13 and IL-10, wherein the cells expressing CD4 and a low level of CD127 and/or a low level CD62L and producing 1) more than 10ng/mL IL-13 when activated or 2) IL-10 and more than 10ng/mL IL-13 when activated, are the IL-13 producing Tr1 cell population.</p> |
