发明名称 |
METHODS OF TREATING <i>S. AUREUS</i>-ASSOCIATED DISEASES |
摘要 |
The present invention provides for methods of preventing and/or treating S. aureus-associated bacteremia and sepsis, and methods for preventing and/or treating S. aureus-associated pneumonia in immunocompromised patients using anti-S. aureus alpha-toxin (anti-AT) antibodies. Also provided are methods of reducing S. aureus bacterial load in the bloodstream or heart of a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof. Methods of reducing S. aureus bacterial agglutination and/or thromboembolic lesion formation in a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof, are also provided. Also provided are methods of preventing or reducing the severity of S. aureus-associated pneumonia in an immunocompromised mammalian subject. |
申请公布号 |
SG11201503231Y(A) |
申请公布日期 |
2015.05.28 |
申请号 |
SG11201503231Y |
申请日期 |
2013.11.05 |
申请人 |
MEDIMMUNE, LLC |
发明人 |
SELLMAN, BRET;TKACZYK, CHRISTINE;HAMILTON, MELISSA;HUA, LEI |
分类号 |
A61K39/085 |
主分类号 |
A61K39/085 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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