TOPICAL LIPOSOMAL COMPOSITIONS FOR DELIVERING HYDROPHOBIC DRUGS AND METHODS PREPARING SAME

摘要

A topical liposomal composition of Amphotricin B (AmB) and method for preparing same, which can be used as a composition and method for preparing topical liposomal compositions of other hydrophobic drugs. The formulation using AmphotricinB can be used for treating fungal or protozoan infections. The composition is stable with no significant changes in the sizes and AmB content of liposomes after storing at 4° C. and room temperature (22° C.) for more than 20 months. In in vivo and in vitro testing, the compositions exhibit high efficacy in treating cutaneous leishmaniasis.

主权项

1. A topical liposomal composition for delivering hydrophobic drugs comprising:
lipid components between 5% to 15% w/w, wherein said lipid components comprise phospholipid and cholesterol; at least one hydrophobic drug, wherein said at least one hydrophobic drug has a particle size of about 100 nm; a solvent; and a plurality of additives selected from the group consisting of: penetration enhancers, emulsifiers, antioxidants, buffering agents, pH adjusting agents, antimicrobial preservatives, water, and combinations thereof.