ANTHRACENYL-TETRALACTAM MACROCYCLES AND THEIR USE IN DETECTING A TARGET SACCHARIDE

摘要

A water-soluble compound of the formula (I): (Formula (I)) wherein R9 and R10 are suitably hydrophilic substituents, which may be used to selectively bind to a target saccharide such as glucose and which exhibits a detectable spectroscopic response to such binding, thus enabling its use in the detection and correction of blood glucose concentrations in vivo.;

主权项

1. A water-soluble compound of the formula (I): wherein R1 to R8 are each independently selected from hydrogen; optionally substituted alkyl groups; optionally substituted cycloalkyl groups; optionally substituted heterocyclyl groups; optionally substituted alkenyl groups; optionally substituted alkynyl groups; optionally substituted aryl groups; optionally substituted heteroaryl groups; alkoxyl groups; ketone and aldehyde groups; carboxylic acids and carboxylate ions; carboxylate esters; —SO3H; —SO3−; —OSO3H; —OSO3−; —PO3XY where X and Y are independently hydrogen, alkyl or a negative charge; —OPO3XY where X and Y are independently hydrogen, alkyl or a negative charge; amines; amides; halo groups; —CN; —NO2; —OH; and imino and imido groups, provided that in any one or more of the pairs R1R2, R3R4, R5R6 and R7R8, the two substituents may be joined together to form part of an optionally substituted cyclic group; and R9 and R10 are each independently selected from hydrogen; optionally substituted alkyl groups; optionally substituted cycloalkyl groups; optionally substituted heterocyclyl groups; optionally substituted alkenyl groups; optionally substituted alkynyl groups; optionally substituted aryl groups; optionally substituted heteroaryl groups; alkoxyl groups; ketone and aldehyde groups; carboxylic acids and carboxylate ions; carboxylate esters; —SO3H; —SO3−; —OSO3H; —OSO3−; —PO3XY where X and Y are independently hydrogen, alkyl or a negative charge; —OPO3XY where X and Y are independently hydrogen, alkyl or a negative charge; amines; amides; halo groups; —CN; —NO2; —OH; and imino and imido groups.