| 主权项 |
1. A drug delivery composition comprising a self-assembled nanostructure and a biologically active molecule, wherein the nanostructure comprises a plurality of surfactant peptides and wherein the surfactant peptides have a formula selected from the group consisting of:
a. (Φ)m(+)n (Formula (1)), b. (+)n(Φ)m (Formula (2)), c. (Φ)m(−)n (Formula (3)), d. (−)n(Φ)m (Formula (4)), e. (−)n(Φ)m(−)n (Formula (5)), f. (+)n(Φ)m(+)n (Formula (6)), g. (Φ)m(−)n(Φ)m (Formula (7)), h. (Φ)m(+)n(Φ)m (Formula (8)), i. (+)n(Φ)m(−)n (Formula (9)), and j. (−)n(Φ)m(+) (Formula (10)), wherein: (Φ) represents independently for each occurrence, a natural or non-natural amino acid comprising a hydrophobic side-chain; (+) represents independently for each occurrence a natural or non-natural amino acid comprising a side-chain that is cationic at physiological pH; (−) represents independently for each occurrence a natural or non-natural amino acid comprising a side-chain that is anionic at physiological pH; wherein the terminal amino acids are optionally substituted; m for each occurrence represents an integer greater than or equal to 5; and n for each occurrence represents an integer greater than or equal to 1;and further wherein the biologically active agent is encapsulated within the nanostructure. |
