MITOGEN-ACTIVATED PROTEIN KINASE-DEPENDENT RECOMBINANT VACCINIA VIRUS (MD-RVV) AND USE THEREOF

摘要

Provided is a vaccinia virus that specifically grows in cancer cells and destroys the cancer cells. Also provided is utilization of said virus in cancer treatment. A mitogen-activated protein kinase-dependent vaccinia virus that lacks a vaccinia virus growth factor (VGF) and O1L function, specifically grows in cancer cells but does not grow in normal cells, and has oncolytic properties for specifically destroying the cancer cells.