发明名称 |
TERT-BUTYL N-[2-{4-[6-AMINO-5-(2,4-DIFLUOROBENZOYL)-2-OXOPYRIDIN-1(2H)-YL]-3,5- DIFLUOROPHENYL}ETHYL]-L-ALANINATE OR A SALT, HYDRATE OR SOLVATE THEREOF |
摘要 |
The present invention provides a compound which is: tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl)-L-alaninate or a salt, hydrate or solvate thereof. The present invention also provides a pharmaceutical composition comprising the compound together with one or more pharmaceutically acceptable carriers and/or excipients. The compound and composition are useful for inhibiting the activity of a p38 MAP kinase enzyme. As such they may be used in the treatment of a autoimmune or inflammatory disease, or a cell proliferative disease. In addition, the invention provides an acid produced by hydrolysis of the ester group of the compound of the invention. The acid is N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl)-L-alanine. |
申请公布号 |
SG11201502515V(A) |
申请公布日期 |
2015.05.28 |
申请号 |
SG11201502515V |
申请日期 |
2013.10.15 |
申请人 |
CHROMA THERAPEUTICS LTD |
发明人 |
PINTAT, STÉPHANE;DAVIES, STEPHEN, JOHN;MOFFAT, DAVID, FESTUS, CHARLES |
分类号 |
C07D213/73;A61K31/4412;A61P29/00;A61P35/00 |
主分类号 |
C07D213/73 |
代理机构 |
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地址 |
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