Present invention relates to methods for preparing (1α,2β,4β,5α,7β)-7-[(hydroxidi-2-thienllacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane-bromide.
申请公布号
US2015148540(A1)
申请公布日期
2015.05.28
申请号
US201514605618
申请日期
2015.01.26
申请人
BILGIC Mahmut
发明人
BILGIC Mahmut
分类号
C07D451/00
主分类号
C07D451/00
代理机构
代理人
主权项
1. A synthesis method so as to be used in the synthesis of tiotropium bromide, wherein said method comprises transforming di-(2-thienyl)-acetic acidinto formula 2C;obtaining scopine ester shown in formula 4C as a consequence of the reaction of the obtained acid anhydride with scopine;obtaining the compound demonstrated in formula 5C after the obtained scopine ester is quaternized with methyl bromide;then processing this compound obtained at the end with organic and/or inorganic basic substances and transforming it into tiotropium bromide.
