| 主权项 |
1. A compound of formula (Ia) or (Ib) wherein B is C1-C4-alkylene, C2-C4-alkenylene, C2-C4-alkynylene, C3-C5-cycloalkyl, R1 and R2, are independently selected from hydrogen, C1-C7-alkyl optionally substituted by C3-C5-cycloalkyl; C1-C7-hydroxyalkyl, C1-C7-alkoxyalkyl, C1-C7-haloalkyl, C3-C5-cycloalkyl, R1 and R2 together with the nitrogen atom to which they are attached, form a azaspirocycloalkyl, a bicyclic ring or heterocycloalkyl which can be substituted by 1 to 3 substituents independently selected from the group consisting of halogen, C1-C7-alkyl, C1-C7-alkoxyalkyl; C1-C7-hydroxyalkyl, C1-C7-alkoxy, C1-C7 haloalkyl, hydroxyl, —NR9R10 and oxo; R3 is selected from hydrogen, C3-C5-cycloalkyl, C1-C7-alkoxyalkyl, C1-C7-haloalkyl, heterocycloalkyl, —(CH2)0,1,2-aryl optionally substituted by C1-C7-alkoxy and C1-C7-alkyl optionally substituted by C3-C5-cycloalkyl; R4 is selected from heteroaryl optionally substituted by 1 to 3 substituents selected from halogen, C1-C7-alkyl, C1-C7-hydroxyalkyl, C1-C7-haloalkoxy, C1-C7-haloalkyl, C3-C5-cycloalkyl, cyano, amino, nitro, —O—R6—C(O)—R7, —SO2R8, C1-C2-alkoxy optionally substituted by C1-C2-alkoxy, heterocycloalkyl, R6 and R8 are selected from C1-C7-alkyl, R7 is selected from heterocycloalkyl, R9 and R10 are independently selected from hydrogen, C1-C7-alkyl, C(O)—O— C1-C7-alkyl. |
