发明名称 |
METHOD FOR INHIBITING GROWTH OF CANCER CELLS |
摘要 |
A method of inhibiting the growth of cancer cells is disclosed in which cancer cells that contain an enhanced amount relative to non-cancerous cells of one or more of phosphorylated mTOR, Akt1, ERK2 and serine2152-phosphorylated filamin A are contacted with an FLNA-binding effective amount of a compound or a pharmaceutically acceptable salt thereof that binds to the pentapeptide of filamin A (FLNA) of SEQ ID NO: 1 and exhibits at least about 60 percent of the FITC-labeled naloxone binding amount when present at a 10 μM concentration and using unlabeled naloxone as the control inhibitor at the same concentration. A compound that binds to the FLNA pentapeptide preferably also contains at least four of the six pharmacophores of FIGS. 19-24. |
申请公布号 |
US2015148318(A1) |
申请公布日期 |
2015.05.28 |
申请号 |
US201414497816 |
申请日期 |
2014.09.26 |
申请人 |
Pain Therapeutics, Inc. |
发明人 |
Wang Hoau-Yan;Burns Barbier Lindsay |
分类号 |
A61K31/395;A61K31/40;A61K31/445;A61K31/426;A61K31/495;A61K31/54;A61K31/551;A61K31/472;A61K31/47;A61K31/4741;A61K31/625;A61K31/5377;A61K31/435;A61K31/485;A61K31/5375 |
主分类号 |
A61K31/395 |
代理机构 |
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代理人 |
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主权项 |
1. A method of inhibiting the growth of cancerous cells that contain an enhanced amount of one or more of phosphorylated-mTOR, phosphorylated-Akt1, phosphorylated-ERK2 and serine2152-phosphorylated filamin A that comprises contacting said cancer cells with an FLNA-binding effective amount of a compound or a pharmaceutically acceptable salt thereof that binds to the pentapeptide of FLNA of SEQ ID NO: 1 and exhibits at least about 60 percent of the FITC-labeled naloxone binding amount when present at a 10 μM concentration, using unlabeled naloxone as the control inhibitor at the same concentration, wherein said enhanced amount of phosphorylated-mTOR, phosphorylated-Akt1, phosphorylated-ERK2 and serine2152-phosphorylated filamin A being an amount that is significantly greater than the amount present in a non-cancerous cell of the same type. |
地址 |
Austin TX US |