| 发明名称 |
SYSTEMS AND METHODS FOR DETECTING MOLECULAR INTERACTIONS USING MAGNETIC BEADS |
| 摘要 |
Systems and methods are provided for detecting or measuring binding affinity between different compositions. The methods include contacting one or more magnetic beads having a surface including a first composition with a substrate having a surface including a second composition; applying a rotating magnetic field to the one or more magnetic beads effective to cause the one or more magnetic beads to move across the surface of the substrate; measuring the movement of the one or more magnetic beads across the substrate surface to determine a translational velocity; and determining a binding affinity between the first and second compositions from the translational velocity. |
| 申请公布号 |
US2015147821(A1) |
申请公布日期 |
2015.05.28 |
| 申请号 |
US201314401493 |
申请日期 |
2013.05.15 |
| 申请人 |
Massachusetts Institute of Technology |
发明人 |
Sing Charles E.;Steimel Joshua P.;Alexander-Katz Alfredo |
| 分类号 |
G01N33/543 |
主分类号 |
G01N33/543 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for detecting or measuring binding affinity between different substrates comprising:
contacting one or more magnetic beads having a surface which comprises a first composition with a substrate having a surface which comprises a second composition, wherein the first composition differs from second composition; applying a rotating magnetic field to the one or more magnetic beads effective to cause the one or more magnetic beads to move across the surface of the substrate; measuring the movement of the one or more magnetic beads across the substrate surface to determine a translational velocity; and determining a binding affinity between the first and second compositions from the translational velocity. |
| 地址 |
Cambridge MA US |
