SEROLOGICAL MARKERS FOR CANCER DIAGNOSIS USING BLOOD SAMPLE

摘要

The present invention relates to a method for diagnosing cancer using information on the aberrant glycosylation of a glycoprotein involved in cancer progress. More particularly, the present invention relates to a cancer diagnosis peptide marker which is screened by the steps of: separating a glycoprotein aberrantly glycosylated according to the occurrence and progress of cancer from the blood of a lung cancer patient by using lectin; and selecting a marker peptide produced by the hydrolysis of the glycoprotein isolated by lectin. The marker peptide can be effectively used as a cancer diagnosis marker and for the diagnosis of cancer.

主权项

1. A method for diagnosing cancer, said method comprising
1) separating and concentrating glycoproteins from the sample obtained from a test subject; 2) preparing polypeptides by hydrolyzing the glycoproteins of step 1); 3) sequencing and quantitative-analyzing the polypeptides of step 2); and 4) diagnosing the test subject with high risk of cancer or with cancer if the polypeptide composed of the amino acid sequence represented by SEQ ID NO:1 or the polypeptide having the molecular weight of 1191.6 is detected from the sequencing or quantitative analysis of step 3).