Intraocular Formulation

摘要

Biodegradable therapeutic agent incorporating microspheres formulated in a high viscosity carrier suitable for intraocular administration to treat an ocular condition. The formulation can also be used to treat non-ocular conditions such as articular pathologies

主权项

1. A biocompatible, injectable intraocular drug delivery system comprising:
(a) a plurality of biodegradable microspheres; (b) a therapeutic agent incorporated by the microspheres; and (c) a viscous carrier for the microspheres, the viscous carrier having a viscosity at 25° C. of between about 140,000 cps and about 500,000 cps at a shear rate of 0.1/second, thereby forming a biocompatible, injectable intraocular drug delivery system, wherein the viscous carrier is a partially crosslinked hyaluronic acid, and wherein the microspheres comprise a poly(lactide-co-glycolide) (PLGA) polymer, the drug delivery system such that about one hour after intravitreal injection of the drug delivery system about 5% or less of the microspheres are present in the vitreous free of the viscous carrier.