PROTECTION OF MATERIALS BY SPHINGOSINE BASED COMPOUNDS

摘要

The invention relates to the use of sphingosine based compounds, in particular phytosphingosine compounds, in the protection of hydroxyapatite containing materials such as teeth and bone. Such compounds are especially useful in the treatment and prevention of dental caries, dental erosion, dentine hypersensitivity and tartar (dental calculus) formation. Methods and devices are also provided for preventing biofilm formation using sphingosine based compounds. Compositions comprising sphingosine based compounds are also provided.

主权项

1. Sphingosine compound having formula I: wherein X is an alkyl or alkenyl having 8-24 carbons, preferably 10 to 20 carbons, more preferably a linear alkyl; R1 is selected from H and C(═O)C1-20, preferably R1 is H; R2 is selected from H and OH, preferably R2 is OH; and R3 is selected from phosphate, OH or F, preferably OH, or a conjugate of said compound, for use as a coating on tooth or bone.