| 发明名称 |
MIXED MULTIFUNCTIONAL METAL AFFINITY SURFACES FOR REDUCING AGGREGATE CONTENT IN PROTEIN PREPARATIONS |
| 摘要 |
Compositions for reducing the aggregate content of a protein preparation include a first substrate having a first surface-bound ligand possessing a metal affinity functionality and a second surface-bound ligand optionally provided on a second substrate and having an aggregate charge opposite to that of the metal affinity functionality of the first substrate, wherein the first surface-bound ligand and the second surface-bound ligand are positioned such that the protein preparation may contact both the first surface-bound ligand and the second surface-bound ligand simultaneously. |
| 申请公布号 |
US2015147243(A1) |
申请公布日期 |
2015.05.28 |
| 申请号 |
US201414555165 |
申请日期 |
2014.11.26 |
| 申请人 |
Agency for Science, Technology and Research |
发明人 |
Gagnon Peter |
| 分类号 |
C07K16/32;B01D15/38;B01D15/34;C07K16/00;B01D15/36 |
主分类号 |
C07K16/32 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition of matter for reducing the aggregate content of a protein preparation, comprising a first substrate comprising a first surface-bound ligand possessing a metal affinity functionality and a second surface-bound ligand optionally provided on a second substrate and having an aggregate charge opposite to that of the metal affinity functionality of the first substrate, wherein the first surface-bound ligand and the second surface-bound ligand are positioned such that the protein preparation may contact both the first surface-bound ligand and the second surface-bound ligand simultaneously. |
| 地址 |
Connexis SG |
