| 发明名称 |
LEDGF PEPTIDES AND FORMULATIONS THEREOF FOR TREATMENT OF DEGENERATIVE DISORDERS |
| 摘要 |
LEDGF peptides with anti-protein aggregation activity and methods of use are provided. The LEDGF peptides disclosed herein demonstrate an ability to treat degenerative diseases and diseases with various cellular stresses including oxidative stress and protein-aggregation stress. In addition, extended release formulations, including formulations suitable for ophthalmic administration are provided. |
| 申请公布号 |
US2015147404(A1) |
申请公布日期 |
2015.05.28 |
| 申请号 |
US201314402426 |
申请日期 |
2013.05.21 |
| 申请人 |
The Regents of the University of Colorado, a body corporate |
发明人 |
Kompella Uday B.;Baid Rinku;Upadhyay Arun K.;Yandrapu Sarath |
| 分类号 |
A61K38/18;A61K47/48;C07K14/475 |
主分类号 |
A61K38/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A peptide comprising an amino acid sequence of lens epithelium derived growth factor (LEDGF), wherein the peptide comprises a LEDGF N-terminal stress related binding domain. |
| 地址 |
Denver CO US |
