发明名称 |
COMPOSITIONS COMPRISING CYCLIC PURINE DINUCLEOTIDES HAVING DEFINED STEREOCHEMISTRIES AND METHODS FOR THEIR PREPARATION AND USE |
摘要 |
It is an object of the present invention to provide novel and highly active cyclic-di-nucleotide (CDN) immune stimulators that activates DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides that induce STING-dependent TBK1 activation, wherein the cyclic purine dinuclotides present in the composition are substantially pure Rp,Rp or Rp,Sp stereoisomers, and particularly substantially pure Rp,Rp, or RpSp CDN thiophosphate diastereomers. |
申请公布号 |
SG11201502796R(A) |
申请公布日期 |
2015.05.28 |
申请号 |
SG11201502796R |
申请日期 |
2013.12.13 |
申请人 |
ADURO BIOTECH, INC. |
发明人 |
DUBENSKY, JR.,THOMAS, W.;KANNE, DAVID, B.;LEONG, MEREDITH, LAI LING;LEMMENS, EDWARD, EMILE;GLICKMAN, LAURA, HIX |
分类号 |
C07H21/00;A61P37/02;A61P37/04 |
主分类号 |
C07H21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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