| 发明名称 |
OLEANOYL PEPTIDE COMPOSITION AND COLLAGEN ENHANCEMENT |
| 摘要 |
Disclosed is the a method of skin repair and firming, said method comprising the step of bringing into contact a pentapeptide conjugate of oleanolic acid with skin cells so that the effect of increased cellular communication at the molecular level to bring about gene and protein expression in the cells of the skin that enable repair and firming is realized. The invention demonstrates the effect of the pentapeptide conjugate of oleanolic acid in increasing Transforming Growth Factor-β and Fibroblast Growth Factor gene expressions in the skin. |
| 申请公布号 |
US2015148297(A1) |
申请公布日期 |
2015.05.28 |
| 申请号 |
US201514614538 |
申请日期 |
2015.02.05 |
| 申请人 |
Majeed Muhammed;Nagabhushanam Kalyanam |
发明人 |
Majeed Muhammed;Nagabhushanam Kalyanam |
| 分类号 |
A61K8/64;A61Q19/04;A61Q19/08 |
主分类号 |
A61K8/64 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of increasing the expression of Transforming Growth Factor-β in human fibroblasts, said method comprising step of bringing into contact human fibroblast cells with effective concentration of the composition containing peptide of SEQ ID No. 1 linked to oleanolic acid represented by STR#1 to bring about the regulation of extracellular matrix protein, in particular collagen synthesis. |
| 地址 |
Edison NJ US |
