主权项 |
1. A compound of Formula I: wherein
R1 is hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, or heterocycle;R2 is H, OH, an amino acid or peptide, or ORx wherein Rx is alkyl, cycloalkyl, aryl, heteroaryl, heterocycle, or an oxygen protecting group;Y is nitro, amino, —NHRy, or —N(Ry)2 wherein each Ry is independently alkyl, cycloalkyl, aryl, heteroaryl, heterocycle, a nitrogen protecting group, or a nitrogen bonded to an amino acid;Z is O, S, or H, and the dashed line to Z is an optionally present bond that is absent when Z is H;A3 is carbon;A4 is carbon or nitrogen;A5 is carbon, or nitrogen provided A6 is not a direct bond;A6 is carbon or a direct bond;each of A3-A6 are optionally substituted with one or two alkyl, alkoxy, fluoro, optionally protected hydroxy, aryl, (aryl)alkyl, heteroaryl, heterocycle, cycloalkyl, alkanoyl, alkoxycarbonyl, optionally protected amino, optionally protected aminoalkyl, optionally protected alkylamino, dialkylamino, acylamino, trifluoromethyl, trifluoromethoxy, optionally protected carboxy, optionally protected carboxyalkyl, keto, arylsulfonyl, cyano, or azide groups, or when nitrogen, one nitrogen protecting group; andwherein each alkyl, cycloalkyl, aryl, heteroaryl, or heterocycle of any R1, R2, Rx, or Ry is optionally substituted with one to five alkyl, alkoxy, fluoro, optionally protected hydroxy, aryl, (aryl)alkyl, heteroaryl, heterocycle, cycloalkyl, alkanoyl, alkoxycarbonyl, optionally protected amino, optionally protected aminoalkyl, optionally protected alkylamino, dialkylamino, alkylaminoalkyl, dialkylaminoalkyl, acylamino, trifluoromethyl, trifluoromethoxy, optionally protected carboxy, optionally protected carboxyalkyl, keto, arylsulfonyl, cyano, or azide groups;or a salt or solvate thereof. |