USE OF ALKANOYL L-CARNITINE IN COMBINATION WITH CHEMOTHERAPEUTIC AGENTS FOR TREATMENT OF NEOPLASMS

摘要

PROBLEM TO BE SOLVED: To provide a method of preventing or treating proliferative diseases or diseases that may be associated with or triggered by persistent angiogenesis in a mammal.SOLUTION: The present invention provides the use of an alkanoyl L-carnitine selected from the group consisting of acetyl, propionyl, valeryl, isovaleryl and butyryl L-carnitine, in combination with one or more chemotherapeutic agent selected from the group consisting of: a camptothecin derivative; an alkylating agent; an antineoplastic antimetabolite; a platin compound; a topoisomerase inhibitor; a VEGF inhibitor; a tyrosine kinase inhibitor; an EGFR kinase inhibitor; an mTOR kinase inhibitor; an insulin-like growth factor I inhibitor; a Raf kinase inhibitor; a monoclonal antibody; a proteasome inhibitor; a HDAC inhibitor; toxins; and imides; for treatment of neoplasms.