POLYMORPHS OF DARUNAVIR

摘要

The present invention provides new pseudopolymorphic forms of darunavir as well as a novel amorphous form of darunavir, pharmaceutical compositions comprising these compounds, methods for their preparation and use thereof in treating retroviral infections, in particular, HIV infection.

主权项

1. A process for preparing a solid amorphous form of darunavir characterized by an IR spectrum with characteristic peaks at about 1454 and 1369 cm−1, the process comprising the steps of:
(a) dissolving darunavir in CH2Cl2; and (b) evaporating the CH2Cl2 until a precipitate is formed.