| 发明名称 | 一种沃替西汀化合物 | ||
| 摘要 | 本发明属于医药技术领域，具体涉及一种沃替西汀水合物及其制备方法，本发明得到的沃替西汀晶体，含有一个半结晶水，具有的优点：纯度高，稳定性好。本发明还涉及使用这种沃替西汀水合物制造治疗重度抑郁的药物中的应用。 | ||
| 申请公布号 | CN104650003A | 申请公布日期 | 2015.05.27 |
| 申请号 | CN201310591418.X | 申请日期 | 2013.11.22 |
| 申请人 | 天津市汉康医药生物技术有限公司 | 发明人 | 严洁;李轩 |
| 分类号 | C07D295/096(2006.01)I;A61K31/495(2006.01)I;A61P25/24(2006.01)I | 主分类号 | C07D295/096(2006.01)I |
| 代理机构 | 代理人 | ||
| 主权项 | 式Ⅰ所示氢溴酸沃替西汀的水合物，<img file="201310591418X100001dest_path_image001.GIF" wi="367" he="222" /> （Ⅰ） 用卡尔费休法测定，所述水合物含有6.54%—6.74% 的水分；所述氢溴酸沃替西汀水合物的晶体，用CuKa射线作为特征X射线粉末测定中，其图谱具有下列2θ衍射角和D值，<tables num="0001" id="ctbl0001"><table><tgroup cols="4"><colspec colname="c001" colwidth="23%" /><colspec colname="c002" colwidth="25%" /><colspec colname="c003" colwidth="25%" /><colspec colname="c004" colwidth="24%" /><tbody><row><entry morerows="1">谱线号</entry><entry morerows="1">2θ（度）</entry><entry morerows="1">晶面间距（d）</entry><entry morerows="1">I/I<sub>0</sub></entry></row><row><entry morerows="1">1</entry><entry morerows="1">3.300</entry><entry morerows="1">10.6502</entry><entry morerows="1">40</entry></row><row><entry morerows="1">2</entry><entry morerows="1">6.530</entry><entry morerows="1">6.9750</entry><entry morerows="1">10</entry></row><row><entry morerows="1">3</entry><entry morerows="1">8.980</entry><entry morerows="1">6.3804</entry><entry morerows="1">11</entry></row><row><entry morerows="1">4</entry><entry morerows="1">10.760</entry><entry morerows="1">6.0210</entry><entry morerows="1">16</entry></row><row><entry morerows="1">5</entry><entry morerows="1">12.040</entry><entry morerows="1">5.9031</entry><entry morerows="1">90</entry></row><row><entry morerows="1">6</entry><entry morerows="1">15.470</entry><entry morerows="1">5.0517</entry><entry morerows="1">42</entry></row><row><entry morerows="1">7</entry><entry morerows="1">19.480</entry><entry morerows="1">4.9230</entry><entry morerows="1">13</entry></row><row><entry morerows="1">8</entry><entry morerows="1">20.850</entry><entry morerows="1">4.6045</entry><entry morerows="1">68</entry></row><row><entry morerows="1">9</entry><entry morerows="1">21.940</entry><entry morerows="1">4.3016</entry><entry morerows="1">79</entry></row><row><entry morerows="1">10</entry><entry morerows="1">23.620</entry><entry morerows="1">4.0237</entry><entry morerows="1">10</entry></row><row><entry morerows="1">11</entry><entry morerows="1">25.040</entry><entry morerows="1">3.9406</entry><entry morerows="1">11</entry></row><row><entry morerows="1">12</entry><entry morerows="1">26.120</entry><entry morerows="1">3.7707</entry><entry morerows="1">23</entry></row><row><entry morerows="1">13</entry><entry morerows="1">27.350</entry><entry morerows="1">3.5190</entry><entry morerows="1">24</entry></row><row><entry morerows="1">14</entry><entry morerows="1">29.040</entry><entry morerows="1">3.4382</entry><entry morerows="1">25</entry></row><row><entry morerows="1">15</entry><entry morerows="1">30.820</entry><entry morerows="1">3.3004</entry><entry morerows="1">90</entry></row><row><entry morerows="1">16</entry><entry morerows="1">31.140</entry><entry morerows="1">3.1809</entry><entry morerows="1">7</entry></row><row><entry morerows="1">17</entry><entry morerows="1">33.620</entry><entry morerows="1">3.0043</entry><entry morerows="1">8</entry></row><row><entry morerows="1">18</entry><entry morerows="1">34.940</entry><entry morerows="1">2.6869</entry><entry morerows="1">4</entry></row><row><entry morerows="1">19</entry><entry morerows="1">36.600</entry><entry morerows="1">2.2295</entry><entry morerows="1">3</entry></row><row><entry morerows="1">20</entry><entry morerows="1">40.040</entry><entry morerows="1">2.0133</entry><entry morerows="1">7</entry></row></tbody></tgroup></table></tables>2θ衍射角的误差为±0.2。 | ||
| 地址 | 300409 天津市北辰区北辰科技园区华实道88号 | ||